Bouffet E
Children's Department, Royal Marsden Hospital NHS Trust, Sutton, England.
Paediatr Drugs. 2000 Jan-Feb;2(1):57-66. doi: 10.2165/00148581-200002010-00005.
Dramatic advances have been made in the diagnosis of childhood brain tumours thanks to the development of modern imaging techniques. Advances in the management of these tumours have, however, been slow because of the limitations of an aggressive surgical approach and the risks associated with radiotherapy on the growing, and still immature, brain. The role of chemotherapy remains ill-defined in many patients with brain tumours and large variations in practice exist between groups and institutions. This article provides an overview of the most common paediatric brain tumours, mainly gliomas, medulloblastomas, ependymomas, germ-cell tumours and craniopharyngiomas. Considerations regarding the management of brain tumours in very young children are also examined. The long term outcome for children with brain tumours is discussed, stressing the need to focus on quality of life for survivors.
由于现代成像技术的发展，儿童脑肿瘤的诊断取得了显著进展。然而，由于积极手术方法的局限性以及放疗对正在生长且仍未成熟的大脑所带来的风险，这些肿瘤的治疗进展缓慢。在许多脑肿瘤患者中，化疗的作用仍不明确，不同团队和机构在实践中存在很大差异。本文概述了最常见的儿童脑肿瘤，主要是胶质瘤、髓母细胞瘤、室管膜瘤、生殖细胞肿瘤和颅咽管瘤。还探讨了关于极年幼患儿脑肿瘤治疗的相关考量。讨论了脑肿瘤患儿的长期预后，强调了关注幸存者生活质量的必要性。
