Shcherbenko O I, Zelinskaia N I, Parkhomenko R A, Ardatova G V, Hechaeva V N
Russian Center for Roentgeno-Radiology Research, Ministry of Health of the RF, Moscow.
Vopr Onkol. 1999;45(1):95-7.
Out of 108 children with brain tumors, aged 3-15, receiving radiotherapy in 191-1997, cerebral medulloblastoma was identified in 37 (34%). After total or subtotal excision of tumor, the latter were given 4-12 cycles of polychemotherapy. The brain and spinal marrow was exposed to 30-35 Gy followed by aiming 50-55 Gy irradiation of posterior cranial fossa. Three patients received radiation for recurrent tumor. One patient suffered demyelination as complication after repeated exposure. Out of 32 follow-up patients, 19 have survived an average of 33 months while 13 died having survived an average of 21 months. The main causes of failed therapy proved local progression of tumor and dissemination via liquor. Radical extent of surgery was used as the main prognostic factor.
在1991 - 1997年间接受放疗的108名3 - 15岁脑肿瘤患儿中,确诊为髓母细胞瘤的有37例(34%)。肿瘤全切或次全切后,这些患儿接受了4 - 12个周期的多药化疗。脑部和脊髓接受30 - 35 Gy照射,随后对后颅窝进行50 - 55 Gy的靶向照射。3例患者因肿瘤复发接受放疗。1例患者在反复照射后出现脱髓鞘并发症。在32例接受随访的患者中,19例存活,平均存活33个月,13例死亡,平均存活21个月。治疗失败的主要原因是肿瘤局部进展和通过脑脊液播散。手术切除的彻底程度被用作主要的预后因素。