Uauy R, Martínez J I, Rojas C V
Laboratorio de Biología Molecular, Instituto de Nutrición y Tecnología de los Alimentos INTA, Universidad de Chile, Santiago, Chile.
Rev Med Chil. 2000 Apr;128(4):437-46.
PPARs are transcription factors belonging to the super family of hormonal receptors. Their activity is regulated by fibrates, thiazolidinediones, certain anti inflammatory drugs and fatty acid derivatives, present in food. PPAR isoforms play a central role in lipid homeostasis, regulating anabolic (PPAR gamma) and catabolic (PPAR alpha) pathways of lipid metabolism. Additionally, these receptors participate in glucose homeostasis, influence cellular proliferation and differentiation and participate in inflammatory processes. The effects of PPARs on oxidative substrate partitioning suggests that they have a relevant role in the development of obesity and insulin resistance.
过氧化物酶体增殖物激活受体（PPARs）是属于激素受体超家族的转录因子。它们的活性受贝特类药物、噻唑烷二酮类药物、某些抗炎药物以及食物中存在的脂肪酸衍生物的调节。PPAR亚型在脂质稳态中起核心作用，调节脂质代谢的合成代谢（PPARγ）和分解代谢（PPARα）途径。此外，这些受体参与葡萄糖稳态，影响细胞增殖和分化，并参与炎症过程。PPARs对氧化底物分配的影响表明它们在肥胖和胰岛素抵抗的发展中具有重要作用。
