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Enhanced activation of platelets with abnormal release of RANTES in human immunodeficiency virus type 1 infection.人类免疫缺陷病毒1型感染中血小板的激活增强及调节激活正常T细胞表达和分泌的趋化因子异常释放
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Effect of a new monoclonal anti-glycoprotein IX antibody, KMP-9, on high shear-induced platelet aggregation.新型单克隆抗糖蛋白IX抗体KMP-9对高剪切诱导的血小板聚集的影响
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Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets.凝血酶刺激的血小板结合诱导白细胞中细胞因子表达。
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Tyrosine phosphorylation and p72syk activation by an anti-glycoprotein Ib monoclonal antibody.抗糖蛋白Ib单克隆抗体引起的酪氨酸磷酸化和p72syk激活。
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8
High shear stress can initiate both platelet aggregation and shedding of procoagulant containing microparticles.高剪切应力可引发血小板聚集和含有促凝物质的微粒脱落。
Blood. 1996 Nov 1;88(9):3456-64.
9
Activated platelets signal chemokine synthesis by human monocytes.活化的血小板可诱导人单核细胞合成趋化因子。
J Clin Invest. 1996 Mar 15;97(6):1525-34. doi: 10.1172/JCI118575.
10
Elevated levels of soluble E-selectin in patients with IDDM and NIDDM: relation to metabolic control.胰岛素依赖型糖尿病（IDDM）和非胰岛素依赖型糖尿病（NIDDM）患者可溶性E选择素水平升高：与代谢控制的关系。
Diabetologia. 1995 Sep;38(9):1122-4. doi: 10.1007/BF00402185.

趋化因子与活化血小板在糖尿病患者中的意义。

Significance of chemokines and activated platelets in patients with diabetes.

作者信息

Nomura S, Shouzu A, Omoto S, Nishikawa M, Fukuhara S

机构信息

First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.

出版信息

Clin Exp Immunol. 2000 Sep;121(3):437-43. doi: 10.1046/j.1365-2249.2000.01324.x.

DOI:10.1046/j.1365-2249.2000.01324.x
PMID:10971508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1905738/
Abstract

Levels of platelet-derived microparticles (PMPs), platelet activation markers (P-selectin expressed on, or annexin V binding to, platelets (plt:P-selectin or plt:annexin V, respectively)), chemokines (IL-8, monocyte chemotactic peptide-1 (MCP-1), and regulated on activation normally T-cell expressed and secreted (RANTES)), and soluble P- and E-selectins were compared in peripheral blood from diabetic and control patients in order to develop a better understanding of their potential contribution to diabetic vascular complications. Significant increases were found for PMPs, plt:P-selectin, MCP-1, RANTES and soluble P- and E-selectins in diabetic individuals, whereas IL-8 levels were similar. Furthermore, after ticlopidine treatment, most of these factors receded to baseline levels observed in non-diabetic patients. Our findings indicate that ticlopidine might be able to prevent or reduce vascular complications in diabetic patients.

摘要

为了更好地了解血小板衍生微粒（PMPs）、血小板活化标志物（分别为血小板上表达的P-选择素或血小板与膜联蛋白V结合（plt:P-选择素或plt:膜联蛋白V））、趋化因子（白细胞介素-8（IL-8）、单核细胞趋化蛋白-1（MCP-1）和正常T细胞激活时表达和分泌的调节因子（RANTES））以及可溶性P-选择素和E-选择素在糖尿病患者和对照患者外周血中的水平，对其进行了比较。结果发现，糖尿病患者的PMPs、plt:P-选择素、MCP-1、RANTES以及可溶性P-选择素和E-选择素显著增加，而IL-8水平相似。此外，噻氯匹定治疗后，这些因素大多降至非糖尿病患者观察到的基线水平。我们的研究结果表明，噻氯匹定可能能够预防或减少糖尿病患者的血管并发症。