与改用莫达非尼相关的问题——一种用于发作性睡病的新型提神药物。

Problems associated with switch to modafinil - a novel alerting agent in narcolepsy.

作者信息

Guilleminault C, Aftab F A, Karadeniz D, Philip P, Leger D

机构信息

Stanford Sleep Disorders Clinic and Research Center, CA 94605, USA.

出版信息

Eur J Neurol. 2000 Jul;7(4):381-4. doi: 10.1046/j.1468-1331.2000.00087.x.

DOI:10.1046/j.1468-1331.2000.00087.x

PMID:10971596

Abstract

Modafinil is a novel medication recently approved for the treatment of narcolepsy and idiopathic hypersomnia. Commonly, patients had already been prescribed medications for their syndrome. This report outlines difficulties encountered in the clinical practice of switching patients to modafinil. Naïve subjects accepted modafinil best. Subjects withdrawn from amphetamine had the most problems and failure to withdraw. Venlafaxine hydrochloride combined well with modafinil to control cataplectic attacks. Usage of a progressive withdrawal protocol may ease the difficulties observed.

摘要

莫达非尼是一种最近被批准用于治疗发作性睡病和特发性嗜睡症的新型药物。通常情况下，患者已经在服用针对其综合征的药物。本报告概述了在将患者转换为使用莫达非尼的临床实践中遇到的困难。未用过药物的受试者对莫达非尼的接受度最佳。从苯丙胺撤药的受试者问题最多，且撤药失败。盐酸文拉法辛与莫达非尼联合使用可很好地控制猝倒发作。采用逐步撤药方案可能会缓解所观察到的困难。