Omar M H, Ong F B, Adeeb N N, Sharif J M, Nasri N, Yassin M J
Department of Obstetrics & Gynaecology, Universiti Kebangsaan Malaysia, Jalan Tenteram, Cheras, Kuala Lumpur.
Med J Malaysia. 1999 Mar;54(1):65-71.
A survey in 1996 of our female patients suggest that the three commonest causes of infertility were endometriosis, anovulation and idiopathic which comprises of about 70% of all the patients. In the male patients, sperm morphology evaluation by critical criteria showed that abnormal morphology was present in 71% while 87% of all the semen analysis were abnormal. The objective of this study was to assess the status of IUI before proceeding to formulate patient protocols for IVF in a tertiary infertility referral unit. A retrospective study of patients data was done from Jan 1995 to Dec 1996. Ovarian stimulation by clomiphene for anovulatory and idiopathic patients was performed on couples with at least one patent fallopian tube. Ovulation induction was by an intramuscular injection of 5000 i.u of HCG after follicular maturation. IUI was performed approximately 36-40 hours later. A total of 74 couples received 114 treatment cycles producing a total of 9 conceptions. The conception rate of IUI was therefore 7.89% per cycle and 12.16% per couple with the cumulative pregnancy rate of 28.21%. Associated success features of IUI found in this study were the age of the woman and the semen parameters of the husband.
1996年对我们女性患者的一项调查表明，不孕症最常见的三个原因是子宫内膜异位症、无排卵和不明原因，这约占所有患者的70%。在男性患者中，按照严格标准进行的精子形态学评估显示，71%存在形态异常，而所有精液分析中有87%异常。本研究的目的是在一家三级不孕症转诊单位制定体外受精患者方案之前，评估宫腔内人工授精（IUI）的情况。对1995年1月至1996年12月期间患者的数据进行了回顾性研究。对至少有一条输卵管通畅的夫妇，使用克罗米芬对无排卵和不明原因的患者进行卵巢刺激。卵泡成熟后，通过肌肉注射5000国际单位的人绒毛膜促性腺激素（HCG）进行排卵诱导。大约36 - 40小时后进行宫腔内人工授精。共有74对夫妇接受了114个治疗周期，共产生9次妊娠。因此，宫腔内人工授精的妊娠率为每个周期7.89%，每对夫妇12.16%，累积妊娠率为28.21%。本研究中发现的宫腔内人工授精的相关成功因素是女性的年龄和丈夫的精液参数。
