保守非编码序列是调控元件的可靠指引。
Conserved noncoding sequences are reliable guides to regulatory elements.
作者信息
Hardison R C
机构信息
Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
出版信息
Trends Genet. 2000 Sep;16(9):369-72. doi: 10.1016/s0168-9525(00)02081-3.
Abstract
A 'working draft' of the human genome sequence is now available. Comparisons with the sequences of mouse and other species will be a powerful approach to identifying functional segments of the noncoding regions, such as gene regulatory elements. However, the choice of a species for most effective comparison differs among various loci.
摘要
人类基因组序列的“工作草图”现已问世。将其与小鼠及其他物种的序列进行比较，将成为识别非编码区功能片段（如基因调控元件）的有力方法。然而，对于不同的基因座，为实现最有效比较而选择的物种各不相同。
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