Lippa C F, Swearer J M, Kane K J, Nochlin D, Bird T D, Ghetti B, Nee L E, St George-Hyslop P, Pollen D A, Drachman D A
Department of Neurology, Medical College of Pennsylvania-Hahnemann University, Philadelphia, PA, USA.
Ann Neurol. 2000 Sep;48(3):376-9.
Alzheimer's disease (AD) is caused by multiple genetic and/or environmental etiologies. Because differences in the genetically determined pathogenesis may cause differences in the phenotype, we examined age at onset and age at death in 90 subjects with dominantly inherited AD due to different mutations (amyloid precursor protein, presenilin-1, and presenilin-2 genes). We found that among patients with dominantly inherited AD, genetic factors influence both age at onset and age at death.
阿尔茨海默病（AD）由多种遗传和/或环境病因引起。由于基因决定的发病机制差异可能导致表型差异，我们研究了90名因不同突变（淀粉样前体蛋白、早老素-1和早老素-2基因）而患有显性遗传AD的受试者的发病年龄和死亡年龄。我们发现，在患有显性遗传AD的患者中，遗传因素会影响发病年龄和死亡年龄。
