Placidi F, Scalise A, Marciani M G, Romigi A, Diomedi M, Gigli G L
Clinica Neurologica, Università Tor Vergata, Roma, Italy.
Clin Neurophysiol. 2000 Sep;111 Suppl 2:S115-9. doi: 10.1016/s1388-2457(00)00411-9.
The interactions between sleep and epilepsy are well known. A nodal point of the relationship between sleep and epilepsy is represented by pharmacological treatment. Sleep disturbances such as drowsiness are among the most frequent side effects of treatment with antiepileptic drugs, since they can deeply modify both sleep architecture and the sleep-wake cycle. Severe daytime somnolence affects patients' activities and it may facilitate the occurrence of seizures. These considerations underline the importance of antiepileptic drugs having anticonvulsant properties that do not negatively influence sleep and daytime somnolence. In this paper we review some relevant aspects of the effects of antiepileptic drugs on sleep.
睡眠与癫痫之间的相互作用已广为人知。睡眠与癫痫关系的一个关键点体现在药物治疗上。嗜睡等睡眠障碍是抗癫痫药物治疗最常见的副作用之一，因为它们会深刻改变睡眠结构和睡眠 - 觉醒周期。严重的日间嗜睡会影响患者的活动，并且可能促使癫痫发作。这些考量凸显了具有抗惊厥特性且不会对睡眠和日间嗜睡产生负面影响的抗癫痫药物的重要性。在本文中，我们回顾了抗癫痫药物对睡眠影响的一些相关方面。
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