Noda Y, Mamiya T, Manabe T, Nishi M, Takeshima H, Nabeshima T
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8560, Nagoya, Japan.
Peptides. 2000 Jul;21(7):1063-9. doi: 10.1016/s0196-9781(00)00244-8.
This article summarizes our recent finding that the nociceptin system is involved in the regulation of learning and memory. The nociceptin-knockout mice show greater learning ability in the water maze task, an enhanced latent learning in the water finding task, better memory in the passive avoidance task, and further, larger long-term potentiation in the hippocampal CA1 region than wild-type mice. Nociceptin itself induces an impairment of passive avoidance task in wild-type mice, which is reversed by naloxone benzoylhydrazone (NalBzoH). Thus, the nociceptin system seems to play negative roles in learning and memory, and NalBzoH may act as a potent antagonist for the nociceptin receptor.
本文总结了我们最近的发现，即痛敏肽系统参与学习和记忆的调节。与野生型小鼠相比，痛敏肽基因敲除小鼠在水迷宫任务中表现出更强的学习能力，在寻水任务中潜在学习能力增强，在被动回避任务中记忆更好，并且在海马CA1区具有更强的长时程增强。痛敏肽本身会导致野生型小鼠被动回避任务受损，而纳洛酮苯甲酰腙（NalBzoH）可逆转这种损伤。因此，痛敏肽系统似乎在学习和记忆中起负面作用，而NalBzoH可能作为痛敏肽受体的有效拮抗剂。
