Levy M L, Robb M, Allen J, Doherty C, Bland J M, Winter R J
Barnet General Hospital, UK.
Respir Med. 2000 Sep;94(9):900-8. doi: 10.1053/rmed.2000.0861.
We investigated whether hospital-based specialist asthma nurses improved recognition and self-treatment of asthma episodes by patients followed up after attending accident and emergency departments (A&E) for asthma exacerbations. We carried out a randomized prospective controlled trial of adult asthma self-management, following a hospital outpatient nurse consultation in two outer-London District General Hospitals (secondary care centres). The study included 211 adults, over 18 years old (mean age 40 years) who attended for asthma in two accident and emergency departments over 13 months. One hundred and eight evaluable patients were randomized into the control group who continued with their usual medical treatment and were not offered any intervention during the study period. One hundred and three evaluable patients were randomized into the intervention group. They were offered three 6-weekly outpatient appointments with one of two specialist asthma nurses for a structured asthma consultation, after attendance at the accident and emergency department. Following assessment of their asthma treatment and control, the nurses advised patients, through the use of self-management-plans, how to recognize and manage uncontrolled asthma and when to seek medical assistance. Medication and inhaler device type were altered if necessary The primary outcome was patient reported self-management of asthma exacerbations for 6 months. Secondary outcomes were assessed at baseline, 3 months and 6 months. These included home peak flow and symptom diaries, structured telephone questionnaires and audit of general practitioner records to determine utilization of services (6 months before and after A&E). Data were analysed on an intention to treat basis by multiple and logistic regression. The intervention group increased their use of inhaled topical steroids in 31/61 (51%) vs. 15/70 (21%) attacks in controls (OR 3.91 CI 1.8-8.4, P<0.001) and their use of rescue medication in 54/61 (89%) severe attacks vs. 53/70 (76%) controls (OR 2.88 CI 1.1-7.9, P<0.05). Intervention patients had significantly higher (mean 20.1 l min(-1); CI 0.4-39.7; P<0.05) and less variable PEF and significantly lower and less variable symptom scores 6 months after entry. Thirty-four percent of intervention patients vs. 42% controls had severe attacks (61 and 70 respectively, OR 0.96 CI 0.7-1.4) during the 6 months. Intervention patients had fewer days off work than controls in the first 3 months (NS) but similar days off during the 6-month period. Intervention patients had fewer episodes away from work in the first (0.34 vs. 0.54, P = 0.08) and the second 3 months (0.25 vs. 0.30, NS) than the controls. Over 80% of the patients records were audited by their general practitioners; the active group had less routine consultations with the doctor (P = 0.03) and practice nurse (P = 0.03), less consultations for uncontrolled episodes (P = 0.06) and less hospital visits (NS) than the controls. Hospital-based specialist nurses reduced asthma morbidity by improving patient self-management behaviour in acute attacks leading to reduced symptoms, improved lung function, less time off work and fewer consultations with health professionals.
我们调查了在事故与急救科(A&E)因哮喘急性加重就诊后接受随访的患者中,医院专科哮喘护士是否能提高患者对哮喘发作的识别及自我治疗能力。我们在伦敦外的两家地区综合医院(二级护理中心)进行了一项成人哮喘自我管理的随机前瞻性对照试验,该试验在医院门诊护士会诊后开展。研究纳入了211名18岁以上的成年人(平均年龄40岁),他们在13个月内前往两家事故与急救科就诊哮喘。108名可评估患者被随机分为对照组,在研究期间继续接受常规治疗且未接受任何干预。103名可评估患者被随机分为干预组。在他们前往事故与急救科就诊后,为他们提供与两名专科哮喘护士之一进行的三次为期6周的门诊预约,进行结构化哮喘会诊。在评估他们的哮喘治疗与控制情况后,护士通过使用自我管理计划,告知患者如何识别和管理未得到控制的哮喘以及何时寻求医疗帮助。如有必要,会更改药物及吸入装置类型。主要结局是患者报告的6个月内哮喘急性加重的自我管理情况。次要结局在基线、3个月和6个月时进行评估。这些包括家庭峰流速和症状日记、结构化电话调查问卷以及对全科医生记录的审核,以确定服务利用情况(A&E就诊前后6个月)。数据采用意向性分析,通过多元和逻辑回归进行分析。干预组在31/61次(51%)发作中增加了吸入性局部类固醇的使用,而对照组为15/70次(21%)发作(比值比3.91,置信区间1.8 - 8.4,P<0.001);在54/61次(89%)重度发作中增加了急救药物的使用,而对照组为53/70次(76%)发作(比值比2.88,置信区间1.1 - 7.9,P<0.05)。干预组患者在入组6个月后,峰流速显著更高(平均20.1升/分钟;置信区间0.4 - 39.7;P<0.05)且变异性更小,症状评分显著更低且变异性更小。在6个月期间,34%的干预组患者与42%的对照组患者发生了重度发作(分别为61例和70例,比值比0.96,置信区间0.7 - 1.4)。干预组患者在前3个月的误工天数比对照组少(无统计学差异),但在6个月期间的误工天数相似。干预组患者在第一个3个月(0.34对0.54,P = 0.08)和第二个3个月(0.25对0.30,无统计学差异)的缺勤发作次数比对照组少。超过80%的患者记录由其全科医生审核;与对照组相比,干预组与医生的常规会诊(P = 0.03)和实习护士的会诊(P = 0.03)更少,未得到控制发作的会诊(P = 0.06)更少,住院次数(无统计学差异)更少。医院专科护士通过改善患者在急性发作中的自我管理行为,降低了哮喘发病率,从而减轻了症状、改善了肺功能、减少了误工时间并减少了与医护人员的会诊次数。