Moran J J
Pathol Annu. 1975;10:393-417.
The clinical and pathologic features of a group of 62 infants dying of idiopathic calcific arterial disease were reviewed. The disease most commonly occurs in infants less than 6 months of age. Pathologically, it is characterized by calcific deposits along the internal elastic membrane of arteries accompanied by fibrous thickening of the intima which causes luminal narrowing. The arterial lesions are widespread but the resultant luminal narrowing invariably promotes myocardial ischemia, causing the infants' deaths. A definite tendency of the disease to occur in siblings has been noted, but additional patterns of inheritance are not yet apparent. Clinical diagnosis is feasible with radiologic study of arteries of the head, neck, and extremities. There is a similarity of idiopathic calcific arterial disease of infancy to the arterial lesions of metastatic calcification in severe renal disease, calcific arterial lesions noted in conjunction with certain cardiovascular anomalies, and hypervitaminosis D. Certain experimental situations and toxic states can also produce calcific and proliferative vascular lesions.
回顾了一组62例死于特发性钙化性动脉疾病的婴儿的临床和病理特征。该疾病最常发生于6个月以下的婴儿。病理上，其特征为动脉内弹性膜沿线有钙化沉积，并伴有内膜纤维增厚，导致管腔狭窄。动脉病变广泛，但由此导致的管腔狭窄总是会促进心肌缺血，从而导致婴儿死亡。已注意到该疾病在兄弟姐妹中发生有明确的倾向，但尚未发现其他遗传模式。通过对头、颈和四肢动脉进行放射学研究，临床诊断是可行的。婴儿特发性钙化性动脉疾病与严重肾病中的转移性钙化的动脉病变、某些心血管异常相关的钙化性动脉病变以及维生素D过多症相似。某些实验情况和中毒状态也可产生钙化性和增殖性血管病变。
