Hazenberg M D, Hamann D, Schuitemaker H, Miedema F
Department of Clinical Viro-Immunology, CLB, and the Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Nat Immunol. 2000 Oct;1(4):285-9. doi: 10.1038/79724.
HIV-1 infection is characterized by a gradual loss of CD4+ T cells and progressive immune deficiency that leads to opportunistic infections, otherwise rare malignancies and ultimately death. Extensive research over the past two decades has increased our insight into the pathogenic mechanisms underlying these features of HIV-1 infection. Here, we will give a brief overview of the most recent findings and present a model that fits most of the relevant aspects of HIV-1 infection as known. We hypothesize that HIV-1 infection depletes T cell supplies (which are not replaced because of low and static thymic function) by direct infection and killing of cells and through hyperactivation of the immune system.
HIV-1感染的特征是CD4+T细胞逐渐丧失以及进行性免疫缺陷,进而导致机会性感染、罕见的恶性肿瘤,最终导致死亡。过去二十年的广泛研究增进了我们对HIV-1感染这些特征背后致病机制的了解。在此,我们将简要概述最新发现,并提出一个符合已知HIV-1感染大多数相关方面的模型。我们假设,HIV-1感染通过直接感染和杀伤细胞以及免疫系统的过度激活来耗尽T细胞供应(由于胸腺功能低下和静止而无法补充)。