Celius E G, Harbo H F, Egeland T, Vartdal F, Vandvik B, Spurkiand A
Department of Neurology, Oslo City Hospitals, Ullevaal Sykehus, 0407, Oslo, Norway.
J Neurol Sci. 2000 Sep 15;178(2):132-5. doi: 10.1016/s0022-510x(00)00389-0.
The HLA-DR2, DQ6 (i.e., HLA-DRB11501, DQA10102, DQB1*0602) haplotype contributes to the risk of developing multiple sclerosis (MS) in Caucasoids of Northern European heritage. A correlation between the clinical expression of MS and the presence of HLA-DR2, DQ6 has, however, not convincingly been shown. In this study conventional bivariate analysis and logistic regression analysis were used to study the relationship between HLA-DR2, DQ6 and four disease variables in a cohort of 286 Norwegian MS patients from the Oslo area. Logistic regression analysis showed that HLA-DR2, DQ6 was significantly more frequent among female than male patients (P=0. 0251), and was negatively correlated with age at diagnosis regardless of sex (P=0.0254). No significant correlation was observed between HLA-DR2, DQ6 and type of disease (relapsing-remitting versus primary chronic progressive MS) or presence/absence of oligoclonal bands in the cerebrospinal fluid.
HLA - DR2、DQ6单倍型（即HLA - DRB11501、DQA10102、DQB1*0602）会增加北欧血统白种人患多发性硬化症（MS）的风险。然而，MS的临床症状表现与HLA - DR2、DQ6之间的相关性尚未得到令人信服的证实。在本研究中，我们运用传统双变量分析和逻辑回归分析，对来自奥斯陆地区的286名挪威MS患者队列中HLA - DR2、DQ6与四个疾病变量之间的关系进行了研究。逻辑回归分析显示，HLA - DR2、DQ6在女性患者中出现的频率显著高于男性患者（P = 0.0251），且无论性别，其与确诊年龄呈负相关（P = 0.0254）。未观察到HLA - DR2、DQ6与疾病类型（复发缓解型与原发慢性进展型MS）或脑脊液中寡克隆带的有无之间存在显著相关性。
