二甲金刚胺可改善患有实验性阿尔茨海默病动物的学习能力。

Dimebon improves learning in animals with experimental Alzheimer's disease.

作者信息

Lermontova N N, Lukoyanov N V, Serkova T P, Lukoyanova E A, Bachurin S O

机构信息

Laboratory of Neurochemistry, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region.

出版信息

Bull Exp Biol Med. 2000 Jun;129(6):544-6. doi: 10.1007/BF02434871.

DOI:10.1007/BF02434871

PMID:11022244

Abstract

Systemic administration of antihistamine drug dimebon improves active avoidance conditioning in rats with chronic partial deprivation of cerebral cholinergic functions caused by intracerebroventricular injections of AF64A. The effects of dimebon on learning are similar to those of tacrine used in the treatment of Alzheimer's disease.

摘要

全身性给予抗组胺药地美溴铵可改善因脑室内注射AF64A导致慢性部分脑胆碱能功能缺失的大鼠的主动回避条件反射。地美溴铵对学习的影响与用于治疗阿尔茨海默病的他克林的影响相似。