Kuz'min A I, Lodygin D N, Kalenikova E I, Bychkova E Iu, Khokhlova O N, Murashev A N, Medvedev O S
Department of Fundamental Medicine, Moscow State University, Vorob'evy gory, Russia.
Eksp Klin Farmakol. 2000 Jul-Aug;63(4):24-8.
The role of alpha 2-adrenergic and imidazoline receptors in the hemodynamic response to clonidine (manifested by reduced arterial pressure, heart rate, and renal blood flow rate) was studied by injecting their antagonists with different affinity (yohimbine and idazoxan) into narcotized Sprague--Dawley rats. The local introduction (microinjection into rostral ventrolateral medulla) and systemic administration (intraperitoneal injection) of the drugs showed that the hemodynamic effect of clonidine is mediated predominantly by the central alpha 2-adrenergic receptors, rather than by the imidazoline receptors.
通过向麻醉的斯普拉格-道利大鼠注射具有不同亲和力的拮抗剂（育亨宾和伊达唑胺），研究了α2-肾上腺素能受体和咪唑啉受体在可乐定血流动力学反应（表现为动脉压、心率和肾血流速率降低）中的作用。药物的局部注射（微量注射到延髓头端腹外侧）和全身给药（腹腔注射）表明，可乐定的血流动力学效应主要由中枢α2-肾上腺素能受体介导，而非咪唑啉受体。
