Prabhakar S, Syal P, Srivastava T
Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Neurol India. 2000 Sep;48(3):239-42.
Changes in cognitive function are an integral part of the clinical presentation of Parkinson's Disease (PD). P300 potential studies in early stages of Parkinson's disease are lacking and effect of L-dopa therapy on these potentials is controversial. In this study, changes in P300 potentials in early stages of PD and effects of dopaminergic therapy were investigated. P300 waves were elicited by standard auditory 'odd ball' paradigm and were recorded before the start of therapy and 15 days, 3 and 6 months after the start of L-dopa therapy in 25 newly diagnosed patients with idiopathic PD. All patients were classified according to Hoehn and Yahr scale. Minimental status examination (MMSE) was done in all. Control group had 20 normal subjects. The P300 latency was not significantly increased in early Parkinson's disease. This latency was reduced with dopaminergic therapy on 15th day, but increased later. Implications of the data are discussed.
认知功能变化是帕金森病（PD）临床表现的一个组成部分。帕金森病早期的P300电位研究较少，且左旋多巴治疗对这些电位的影响存在争议。在本研究中，对帕金森病早期P300电位的变化及多巴胺能治疗的效果进行了研究。通过标准听觉“odd ball”范式引出P300波，并在25例新诊断的特发性帕金森病患者开始治疗前、开始左旋多巴治疗15天、3个月和6个月后进行记录。所有患者均根据Hoehn和Yahr量表进行分类。对所有患者进行简易精神状态检查（MMSE）。对照组有20名正常受试者。早期帕金森病患者的P300潜伏期没有显著增加。该潜伏期在第15天接受多巴胺能治疗后缩短，但随后又增加。文中讨论了这些数据的意义。
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