α-生育酚氢醌的抗氧化反应

Antioxidant reactions of alpha-tocopherolhydroquinone.

作者信息

Liebler D C, Burr J A

机构信息

Department of Pharmacology and Toxicology and Southwest Environmental Health Sciences Center, College of Pharmacy, The University of Arizona, Tucson 85721-0207, USA.

出版信息

Lipids. 2000 Sep;35(9):1045-7. doi: 10.1007/s11745-000-0617-8.

DOI:10.1007/s11745-000-0617-8

PMID:11026627

Abstract

Alpha-tocopherolhydroquinone (TQH2) is a product of alpha-tocopherol oxidation/reduction that exerts antioxidant effects in biological systems. TQH2 inhibited autoxidation of methyl linoleate initiated by peroxyl radicals derived from thermolysis of 2,2'-azobis(2,4-dimethylvaleronitrile) in acetonitrile. TQH2 oxidation yielded alpha-tocopherolquinone (TQ) as a major product and 2,3-epoxy-alpha-tocopherolquinone and 5,6-epoxy-alpha-tocopherolquinone as minor products. Each TQH2 consumed approximately two peroxyl radicals in the course of the oxidation. The data suggest that TQH2 scavenges peroxyl radicals primarily by electron transfer to form TQ and secondarily by addition-elimination to form the epoxyquinones.

摘要

α-生育酚氢醌（TQH2）是α-生育酚氧化/还原的产物，在生物系统中发挥抗氧化作用。TQH2抑制了由2,2'-偶氮二（2,4-二甲基戊腈）在乙腈中热解产生的过氧自由基引发的亚油酸甲酯的自氧化。TQH2氧化产生α-生育酚醌（TQ）作为主要产物，2,3-环氧-α-生育酚醌和5,6-环氧-α-生育酚醌作为次要产物。在氧化过程中，每个TQH2消耗大约两个过氧自由基。数据表明，TQH2主要通过电子转移形成TQ来清除过氧自由基，其次通过加成-消除形成环氧醌。