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肝素诱导的血小板减少症和血栓形成并发的颅外颈内动脉瘤的血管内修复。

Endovascular repair of an extracranial internal carotid artery aneurysm complicated by heparin-induced thrombocytopenia and thrombosis.

作者信息

van Sambeek M R, Segeren C M, van Dijk L C, van Essen J A, Dippel D W, van Urk H

机构信息

Department of Vascular Surgery, Erasmus University Medical Center and the Interuniversity Cardiology Institute, Rotterdam, The Netherlands.

出版信息

J Endovasc Ther. 2000 Oct;7(5):353-8. doi: 10.1177/152660280000700502.

Abstract

PURPOSE

To report the endovascular treatment of a symptomatic extracranial internal carotid artery (ICA) aneurysm that was complicated by heparin-induced thrombocytopenia and thrombosis.

METHODS AND RESULTS

After undergoing a coronary artery bypass graft procedure, a patient was diagnosed with a symptomatic, 3.5-cm ICA aneurysm by computed tomography and angiography. Via a semiclosed access, an Enduring vascular graft was inserted under controlled back bleeding from the ICA. The patient was recovering uneventfully when routine duplex scanning on the fifth postoperative day suggested multiple thrombi within the graft, which was confirmed by arteriography. Thrombectomy and local fibrinolysis were performed; however, the graft occluded the next day without causing neurological symptoms. Heparin-induced thrombocytopenia was diagnosed by enzyme-linked immunosorbent assay.

CONCLUSIONS

Endovascular repair of high cervical extracranial ICA aneurysms is feasible, and protection against intracerebral embolization can be achieved using a semiclosed technique with controlled back bleeding from the ICA during endograft deployment. However, multiple thrombi or thrombotic occlusion during the postoperative period, particularly in a patient already sensitized to heparin, should direct attention toward possible heparin-induced thrombocytopenia.

摘要

目的

报告1例有症状的颅外颈内动脉(ICA)动脉瘤合并肝素诱导的血小板减少症和血栓形成的血管内治疗情况。

方法与结果

1例患者在接受冠状动脉搭桥手术后,经计算机断层扫描和血管造影诊断为有症状的3.5 cm ICA动脉瘤。通过半封闭入路,在颈内动脉控制性回血的情况下植入了Enduring血管移植物。术后第5天常规双功扫描提示移植物内有多个血栓,动脉造影证实了这一情况,此时患者恢复顺利。进行了血栓切除术和局部纤维蛋白溶解治疗;然而,移植物在第二天闭塞,未引起神经症状。通过酶联免疫吸附测定法诊断为肝素诱导的血小板减少症。

结论

高位颈外ICA动脉瘤的血管内修复是可行的,在植入血管内移植物期间,采用半封闭技术并控制颈内动脉回血可实现对脑内栓塞的预防。然而,术后出现多个血栓或血栓性闭塞,尤其是在已经对肝素敏感的患者中,应注意可能存在肝素诱导的血小板减少症。

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