Efendić S, Cerasi E, Luft R
Diabetologia. 1975 Oct;11(5):407-10. doi: 10.1007/BF00429908.
Starvation of rats for 24 hrs resulted in decreased insulin release from the isolated rat pancreas. The effect of fasting could not be counteracted by elevation of the glucose level in the equilibration medium from 0.8 to 1.5 mg/ml. The alpha-adrenergic blocking agent phentolamine (10 mug/ml) stimulated glucose induced insulin release to approximately the same extent in fasted as in fed rats. These findings illustrate the importance of endogenous catecholamines in the regulation of insulin secretion from the isolated pancreas. Our experiments suggest that the impairment of insulin secretion on fasting is due neither to the inhibitory effect of catecholamines nor to the lack of substrate in the pancreas at the initiation of the stimulation.
大鼠饥饿24小时导致离体大鼠胰腺胰岛素释放减少。将平衡培养基中的葡萄糖水平从0.8毫克/毫升提高到1.5毫克/毫升并不能抵消禁食的影响。α-肾上腺素能阻断剂酚妥拉明（10微克/毫升）在禁食大鼠和进食大鼠中刺激葡萄糖诱导的胰岛素释放的程度大致相同。这些发现说明了内源性儿茶酚胺在离体胰腺胰岛素分泌调节中的重要性。我们的实验表明，禁食时胰岛素分泌受损既不是由于儿茶酚胺的抑制作用，也不是由于刺激开始时胰腺中缺乏底物。
