氟康唑在血清谷浓度约为80微克/毫升时可诱发惊厥。

Fluconazole-induced convulsions at serum trough concentrations of approximately 80 microg/mL.

作者信息

Matsumoto K, Ueno K, Yoshimura H, Morii M, Takada M, Sawai T, Mitsutake K, Shibakawa M

机构信息

Department of Pharmacy, National Cardiovascular Center, Suita-city, Osaka, Japan.

出版信息

Ther Drug Monit. 2000 Oct;22(5):635-6. doi: 10.1097/00007691-200010000-00022.

DOI:10.1097/00007691-200010000-00022

PMID:11034273

Abstract

On the basis of two case reports it is suggested that serious convulsions may occur in patients treated with flucoazole when serum trough concentrations exceed 80 microg/mL. The authors recommend monitoring fluconazole concentrations during high-dose therapy in patients with poor kidney function.

摘要

基于两份病例报告，有人提出，当氟康唑治疗的患者血清谷浓度超过80微克/毫升时，可能会发生严重惊厥。作者建议在对肾功能不佳的患者进行高剂量治疗期间监测氟康唑浓度。