De Leo V, La Marca A, Morgante G, Ciani F, Zammarchi E, Setacci C
Departments of Gynecology and Vascular Surgery, University of Siena, Siena, Italy.
Am J Obstet Gynecol. 2000 Oct;183(4):945-7. doi: 10.1067/mob.2000.106345.
The aim of our randomized, controlled trial was to verify the effect of folic acid supplementation on homocysteine levels in postmenopausal women.
Thirty-six women were divided randomly into 2 groups as follows: a placebo group (n = 18) and a group receiving 500 microg folic acid per day for 4 weeks (n = 18). To assess concentrations of plasma homocysteine, venous blood samples were taken on enrollment and after 4 weeks of treatment.
Mean plasma homocysteine levels were 10.9 +/- 2.7 micromol/L in the placebo group and 7.8 +/- 2.35 micromol/L (P <.01) in the group receiving 500 microg folic acid per day for 4 weeks. The thirds (referred to as tertiles) of women with the highest baseline homocysteine plasma levels showed the greatest reduction in homocysteine, with a mean decrease of 4.35 micromol/L (32%; P <.01), in comparison with a decrease of 3.35 micromol/L (29%; P <.01) in the middle tertile and 1.3 micromol/L (22.4%; P =.09) in the lower tertile.
The results show that low doses of folic acid are associated with a significant reduction in plasma concentrations of homocysteine. The highest initial levels of homocysteine showed the most important reduction after therapy.
我们这项随机对照试验的目的是验证补充叶酸对绝经后女性同型半胱氨酸水平的影响。
36名女性被随机分为以下两组：安慰剂组（n = 18）和每天服用500微克叶酸，持续4周的组（n = 18）。为评估血浆同型半胱氨酸浓度，在入组时和治疗4周后采集静脉血样本。
安慰剂组的平均血浆同型半胱氨酸水平为10.9±2.7微摩尔/升，每天服用500微克叶酸持续4周的组为7.8±2.35微摩尔/升（P<.01）。基线时血浆同型半胱氨酸水平最高的三分之一女性（称为三分位数）同型半胱氨酸降低幅度最大，平均降低4.35微摩尔/升（32%；P<.01），相比之下，中间三分位数降低3.35微摩尔/升（29%；P<.01），最低三分位数降低1.3微摩尔/升（22.4%；P =.09）。
结果表明，低剂量叶酸与血浆同型半胱氨酸浓度显著降低有关。治疗后，初始同型半胱氨酸水平最高者降低幅度最为显著。
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