Holm T, Cedermark B, Johansson H, Singnomklao T, Rutqvist L E
Kirurgiska kliniken, Karolinska Sjukhuset, Stockholm.
Lakartidningen. 2000 Aug 23;97(34):3582-6.
The aim of the Stockholm Colorectal Cancer Study Group is to improve treatment results in colorectal cancer. Between 1980 and 1993 the group conducted two randomised trials on preoperative radiotherapy in rectal cancer including 1406 patients. In both trials radiotherapy significantly reduced local recurrence and improved cancer specific survival. To further improve treatment results, four workshops have been held to introduce the "TME concept" to surgeons in Stockholm. The workshops included live surgical demonstrations and histopathology sessions. When patients included in the Stockholm trials (1980-1993) were compared to patients included in the "TME project" (1995-1996) the rate of abdominoperineal procedures was reduced from 60 to 27 per cent. Within two years of follow up the local recurrence rate was reduced from 15 to 6 per cent and cancer related deaths from 16 to 9 per cent. It is concluded that surgical teaching initiatives may have a significant impact on cancer outcomes.
斯德哥尔摩结直肠癌研究小组的目标是改善结直肠癌的治疗效果。1980年至1993年间,该小组对直肠癌术前放疗进行了两项随机试验,涉及1406名患者。在这两项试验中,放疗均显著降低了局部复发率,并提高了癌症特异性生存率。为了进一步改善治疗效果,已举办了四次研讨会,向斯德哥尔摩的外科医生介绍“全直肠系膜切除术概念”。研讨会包括现场手术演示和组织病理学课程。将斯德哥尔摩试验(1980 - 1993年)纳入的患者与“全直肠系膜切除术项目”(1995 - 1996年)纳入的患者进行比较时,腹会阴联合切除术的比例从60%降至27%。在随访的两年内,局部复发率从15%降至6%,癌症相关死亡率从16%降至9%。得出的结论是,外科教学举措可能对癌症治疗结果产生重大影响。