9p21区域杂合性缺失作为p16抑癌基因的失活机制
[Loss of heterozygosity in the 9p21 region as an inactivation mechanism of the p16 suppressor gene].
作者信息
Maestro de las Casas M L, Sanz-Casla M T, del Barco V, Moreno J, Zanna I, Redondo E, Fernández C, Izquierdo L, Resel Estévez L
机构信息
Servicio de Análisis Clínicos, Hospital Universitario San Carlos, Madrid.
出版信息
Arch Esp Urol. 2000 Sep;53(7):603-9.
OBJECTIVE
To determine the loss of heterozygosity (LOH) on 9p21 (locus D9S1747) in patients with renal carcinoma by analysis of microsatellite polymorphisms.
METHODS
40 patients with sporadic renal cancer were studied. LOH on 9p21 was performed by analysis of microsatellite polymorphisms.
RESULTS
23.7% showed LOH on 9p21. No correlation was found between this genetic alteration and tumor features.
CONCLUSIONS
LOH on 9p21 was found in 23.7% of the patients in this series. LOH was found in 26.9% of renal cell carcinomas, 25% of papillary carcinomas and 25% of Bellini duct carcinomas. LOH was not found in the other histological types.
目的
通过微卫星多态性分析确定肾癌患者9p21（基因座D9S1747）上的杂合性缺失（LOH）。
方法
对40例散发性肾癌患者进行研究。通过微卫星多态性分析检测9p21上的LOH。
结果
23.7%的患者在9p21上显示杂合性缺失。未发现这种基因改变与肿瘤特征之间存在相关性。
结论
本研究系列中23.7%的患者存在9p21杂合性缺失。在26.9%的肾细胞癌、25%的乳头状癌和25%的肾集合管癌中发现了杂合性缺失。在其他组织学类型中未发现杂合性缺失。
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