健康供者使用粒细胞集落刺激因子（G-CSF）进行外周血干细胞（PBSC）动员后的罕见不良事件。

Unusual adverse events following peripheral blood stem cell (PBSC) mobilisation using granulocyte colony stimulating factor (G-CSF) in healthy donors.

作者信息

Hilbe W, Nussbaumer W, Bonatti H, Thaler J, Niederwieser D, Nachbaur D

机构信息

BMT Unit, Dept of Internal Medicine, Innsbruck University Hospital, Innsbruck, Austria.

出版信息

Bone Marrow Transplant. 2000 Oct;26(7):811-3. doi: 10.1038/sj.bmt.1702581.

DOI:10.1038/sj.bmt.1702581

PMID:11042668

Abstract

Here, we describe two cases of severe pyogenic infection in healthy donors diagnosed immediately following stem cell mobilisation with G-CSF. In the first donor a painful perianal abscess and in the second one an apical abscess required surgical incision. The reported serious adverse events in the literature are reviewed and the potential pathophysiological role of G-CSF or GM-CSF in augmenting inflammatory processes is discussed. In the light of a rapidly increasing number of related and unrelated peripheral blood stem cell donations the need for more comprehensive donor work-up and follow-up for peripheral blood stem cell donors has to be considered. Bone Marrow Transplantation (2000) 26, 811-813.

摘要

在此，我们描述了两例健康供体在使用粒细胞集落刺激因子（G-CSF）进行干细胞动员后立即被诊断出患有严重化脓性感染的病例。第一例供体出现疼痛性肛周脓肿，第二例出现根尖脓肿，均需要手术切开引流。我们回顾了文献中报道的严重不良事件，并讨论了G-CSF或粒细胞-巨噬细胞集落刺激因子（GM-CSF）在加剧炎症过程中可能的病理生理作用。鉴于相关和非相关外周血干细胞捐献数量迅速增加，必须考虑对外周血干细胞供体进行更全面的术前检查和术后随访。《骨髓移植》（2000年）第26卷，第811 - 813页。