Killinger Z, Payer J, Sládeková K, Kratochví'lová M, Ondrejka P
I. interná klinika Fakultnej nemocnice, Bratislava.
Vnitr Lek. 1999 Aug;45(8):473-5.
Vitamin D deficiency is one of the important risk factors for the development of osteoporosis and fractures. The high prevalence of hypovitaminosis in elderly people in old age pnesioners homes was proved in several investigations, similarly as the favourable effect of vitamin D (800 IU/day) and calcium supplementation on a decline of fracture risk. Risk factors of hypovitaminosis such as an inadequately varied diet; low exposure to sunlight, chronic liver and kidney disease and treatment affecting the metabolism and clearance of vitamin D are very frequent in elderly patients hospitalized in medical departments. In the submitted trial the authors assessed in a group of 38 patients, mean age 70 years, hospitalized at the medical department at the end of the winter period the vitamin D3 serum level. They found a significant reduction of the concentration of 1.25 hydroxyvitamin D3 (p < 0.01) in the investigated group. The results of the trial, along with data in the literature on the high prevalence of hypovitaminosis D in the European population, indicate the need to introduce this simple cheap and safe therapeutic modality into routine practice.
维生素D缺乏是骨质疏松症和骨折发生的重要危险因素之一。多项调查证实，老年疗养院老年人维生素缺乏症的患病率很高，维生素D（800国际单位/天）和补充钙对降低骨折风险也有积极作用。维生素缺乏症的危险因素，如饮食种类单一、日照不足、慢性肝肾疾病以及影响维生素D代谢和清除的治疗，在医学科室住院的老年患者中非常常见。在提交的试验中，作者评估了一组平均年龄70岁、在冬季末入住医学科室的38名患者的血清维生素D3水平。他们发现，研究组中1,25-二羟维生素D3的浓度显著降低（p<0.01）。该试验结果以及欧洲人群维生素D缺乏症高患病率的文献数据表明，有必要将这种简单、廉价且安全的治疗方式引入常规临床实践。
