Krammer P H
Tumorimmunology Program, German Cancer Research Center, Heidelberg, Germany.
Nature. 2000 Oct 12;407(6805):789-95. doi: 10.1038/35037728.
Apoptosis in the immune system is a fundamental process regulating lymphocyte maturation, receptor repertoire selection and homeostasis. Thus, death by apoptosis is as essential for the function of lymphocytes as growth and differentiation. This article focuses on death receptor-associated apoptosis and the role of CD95 (Apo-1/Fas)-mediated signalling in T-cell and B-cell development and during the course of an immune response. Gaining an insight into these processes improves our understanding of the pathogenesis of diseases such as cancer, autoimmunity and AIDS, and opens new approaches to rational treatment strategies.
免疫系统中的细胞凋亡是调节淋巴细胞成熟、受体库选择和体内平衡的基本过程。因此，凋亡导致的细胞死亡对于淋巴细胞的功能而言，与生长和分化同样重要。本文重点探讨死亡受体相关的细胞凋亡以及CD95（Apo-1/Fas）介导的信号传导在T细胞和B细胞发育以及免疫反应过程中的作用。深入了解这些过程有助于我们更好地理解癌症、自身免疫性疾病和艾滋病等疾病的发病机制，并为合理的治疗策略开辟新途径。
