Malnick S D, Beergabel M, Lurie Y
Department of Internal Medicine C, Kaplan Medical Center, Rehovot Israel.
Ann Pharmacother. 2000 Oct;34(10):1156-64. doi: 10.1345/aph.10017.
To review the literature on the treatment of chronic hepatitis C virus (HCV) infection.
MEDLINE search (1986-December 1999) using key words such as HCV, hepatitis, non-A and non-B hepatitis, as well as terms regarding treatment during that time period.
HCV infection was initially treated with interferon monotherapy, but only a minority of patients responded to long-term therapy. A higher rate of response in both interferon-naïve patients and interferon-relapsers has been achieved by using the combination of interferon and ribavarin. Other treatment regimens including high-dose interferon protocols, ursodeoxycholic acid, amantadine, and nonsteroidal antiinflammatory drugs have been less promising. Many alternative therapies are being investigated.
HCV infection is a major public health problem. It is now possible to achieve a cure in nearly 50% of the patients with this infection. Many additional therapies are being evaluated in order to achieve a higher cure rate.
回顾关于慢性丙型肝炎病毒（HCV）感染治疗的文献。
通过MEDLINE检索（1986年至1999年12月），使用如HCV、肝炎、非甲非乙型肝炎等关键词，以及该时间段内关于治疗的术语。
HCV感染最初采用干扰素单一疗法治疗，但只有少数患者对长期治疗有反应。通过使用干扰素和利巴韦林联合治疗，初治患者和干扰素复发患者的反应率更高。其他治疗方案，包括高剂量干扰素方案、熊去氧胆酸、金刚烷胺和非甾体抗炎药，前景不太乐观。许多替代疗法正在研究中。
HCV感染是一个主要的公共卫生问题。现在有可能使近50%的这种感染患者治愈。正在评估许多其他疗法以实现更高的治愈率。
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