Milas L, Withers H R
Radiology. 1976 Jan;118(1):211-8. doi: 10.1148/118.1.211.
At present, nonspecific immunotherapy of malignant tumors seems to be the most promising among immunotherapeutic modalities. Potent nonspecific immunostimulants, Bacillus Calmette-Guerin (BCG) and Corynebacterium parvum, exhibit an antitumor activity in experimental animals, which is commonly manifested by reduced tumor growth and sometimes by complete regression of tumors. Antitumor effectiveness of these bacteria is largely related to tumor immunogenicity and host immunocompetence. Recently, BCG has frequently been used for clinical immunotherapy and has provided therapeutic benefit in many instances, particularly when combined with chemotherapy, radiotherapy or surgery. Clinical experience with C. parvum is so far limited.
目前，在免疫治疗方法中，恶性肿瘤的非特异性免疫治疗似乎最具前景。强效非特异性免疫刺激剂卡介苗（BCG）和短小棒状杆菌在实验动物中表现出抗肿瘤活性，通常表现为肿瘤生长减缓，有时肿瘤会完全消退。这些细菌的抗肿瘤效果在很大程度上与肿瘤免疫原性和宿主免疫能力有关。最近，卡介苗经常被用于临床免疫治疗，并且在许多情况下都带来了治疗益处，特别是与化疗、放疗或手术联合使用时。到目前为止，短小棒状杆菌的临床经验有限。
