与衰老和永生化相关的基因。

Genes involved in senescence and immortalization.

作者信息

Lundberg A S, Hahn W C, Gupta P, Weinberg R A

机构信息

Whitehead Institute, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.

出版信息

Curr Opin Cell Biol. 2000 Dec;12(6):705-9. doi: 10.1016/s0955-0674(00)00155-1.

DOI:10.1016/s0955-0674(00)00155-1

PMID:11063935

Abstract

Senescence is now understood to be the final phenotypic state adopted by a cell in response to several distinct cell physiological processes, including proliferation, oncogene activation and oxygen free radical toxicity. The role of telomere maintenance in immortalization and the roles of p16(INK4A), p19(ARF), p53 and other genes in senescence are being further elucidated. Significant progress continues to be made in our understanding of cellular senescence and immortalization.

摘要

现在人们认识到，衰老乃是细胞为响应多种不同的细胞生理过程（包括增殖、癌基因激活和氧自由基毒性）而采取的最终表型状态。端粒维持在永生化中的作用以及p16(INK4A)、p19(ARF)、p53和其他基因在衰老中的作用正在得到进一步阐明。我们对细胞衰老和永生化的理解继续取得重大进展。