复苏液体外血液稀释的Sonoclot凝血分析
Sonoclot coagulation analysis of in-vitro haemodilution with resuscitation solutions.
作者信息
Brazil E V, Coats T J
机构信息
Accident and Emergency Department, Royal London Hospital, Whitechapel, UK.
出版信息
J R Soc Med. 2000 Oct;93(10):507-10. doi: 10.1177/014107680009301003.
Abstract
The colloid and crystalloid solutions used for resuscitation should preferably be free from effects on coagulation. In 10 volunteers, the effects of haemodilution with various concentrations of 0.9% sodium chloride and 4% succinylated gelatin were assessed by Sonoclot analysis, which describes the whole coagulation process. Small and moderate haemodilution (up to 40%) with 0.9% sodium chloride promoted coagulation. Similar haemodilution with 4% succinylated gelatin impaired coagulation, and at 60% haemodilution coagulation was very poor. These findings need to be confirmed in vivo and their clinical relevance determined.
摘要
用于复苏的胶体溶液和晶体溶液最好对凝血无影响。在10名志愿者中，通过描述整个凝血过程的Sonoclot分析评估了不同浓度的0.9%氯化钠和4%琥珀酰明胶进行血液稀释的效果。用0.9%氯化钠进行小剂量和中等剂量血液稀释（高达40%）可促进凝血。用4%琥珀酰明胶进行类似的血液稀释会损害凝血功能，在血液稀释60%时凝血功能非常差。这些发现需要在体内得到证实，并确定其临床相关性。
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