Tamaoki J, Taira M, Nishimura K, Nakata J, Nagai A
First Department of Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
J Aerosol Med. 2000 Fall;13(3):239-44. doi: 10.1089/jam.2000.13.239.
Nitric oxide (NO) produced within the respiratory tract can stimulate ciliary motility of airway epithelial cells and hence mucociliary transport. In this study, to determine the role of NO in mucociliary dysfunction in sinobronchial syndrome (SBS), we measured NO concentrations in the exhaled air by chemiluminescence analyzer and nasal clearance time (NCT) by saccharin test. Exhaled NO concentrations in patients with SBS were 39% of those in healthy nonsmokers and 55% of those in healthy smokers. The patients also showed prolonged NCT compared with healthy subjects, and there was a significant negative correlation between exhaled NO concentrations and NCT. Furthermore, concentrations of chloride (Cl) in the sputum supernatant were higher in SBS patients than in healthy subjects, and there was a significant negative correlation between sputum Cl concentrations and exhaled NO concentrations. These results suggest that airway mucociliary clearance is impaired in patients with SBS and that this impairment might result from the reduced production of NO and the impaired availability of the molecule in the mucociliary apparatus.
呼吸道内产生的一氧化氮（NO）可刺激气道上皮细胞的纤毛运动，从而促进黏液纤毛运输。在本研究中，为确定NO在鼻窦支气管综合征（SBS）黏液纤毛功能障碍中的作用，我们通过化学发光分析仪测量呼出气体中的NO浓度，并通过糖精试验测量鼻腔清除时间（NCT）。SBS患者呼出的NO浓度为健康非吸烟者的39%，为健康吸烟者的55%。与健康受试者相比，这些患者的NCT也延长，且呼出的NO浓度与NCT之间存在显著负相关。此外，SBS患者痰液上清液中的氯离子（Cl）浓度高于健康受试者，且痰液Cl浓度与呼出的NO浓度之间存在显著负相关。这些结果表明，SBS患者气道黏液纤毛清除功能受损，这种损害可能是由于NO产生减少以及黏液纤毛装置中该分子的可用性受损所致。
