Hori R, Shimakura M, Aramata Y, Kizawa K, Nozawa I, Takahata M, Minami S
Research Laboratories, Toyama Chemical Co., Ltd., Japan.
Jpn J Antibiot. 2000 Aug;53(8):582-91.
Nephrotoxicity of piperacillin (PIPC) was evaluated in rats after combined administration with furosemide. After intravenous administration of PIPC (1600 mg/kg), the rats showed no change in urinalysis, biochemical analysis of plasma and histopathological analysis. The rats receiving furosemide (100 mg/kg) showed elevation of urinary NAG, BUN and creatinine concentrations, and showed slight degeneration of the renal proximal tubules. The rats receiving PIPC (1600 mg/kg) and furosemide (100 mg/kg) showed elevation of BUN and creatinine concentrations, and showed slight degeneration of the proximal tubules. These changes were comparable to those in rats receiving furosemide alone. The rats receiving cephaloridine (1600 mg/kg) showed elevation of urinary protein, BUN and creatinine concentrations, and showed moderate degeneration and necrosis of the proximal tubules. The nephrotoxicity was enhanced by combination with furosemide. In conclusion, no enhanced effect of nephrotoxicity was observed by combination of PIPC with furosemide.
在大鼠中联合给予呋塞米后评估哌拉西林（PIPC）的肾毒性。静脉注射PIPC（1600mg/kg）后，大鼠的尿液分析、血浆生化分析和组织病理学分析均未显示变化。接受呋塞米（100mg/kg）的大鼠尿NAG、BUN和肌酐浓度升高，肾近端小管出现轻微变性。接受PIPC（1600mg/kg）和呋塞米（100mg/kg）的大鼠BUN和肌酐浓度升高，近端小管出现轻微变性。这些变化与单独接受呋塞米的大鼠相当。接受头孢噻啶（1600mg/kg）的大鼠尿蛋白、BUN和肌酐浓度升高，近端小管出现中度变性和坏死。与呋塞米联合使用时肾毒性增强。总之，未观察到PIPC与呋塞米联合使用对肾毒性有增强作用。
