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起源于小脑并沿下颅神经蔓延的原发性中枢神经系统恶性淋巴瘤

[Primary central nervous system malignant lymphoma originating from the cerebellum and extending along the lower cranial nerves].

作者信息

Sasahara A, Kawamata T, Kubo O, Okami N, Kawamura H, Hori T

机构信息

Department of Neurosurgery, Ushiku-Aiwa General Hospital, Tokyo, Japan.

出版信息

No Shinkei Geka. 2000 Oct;28(10):879-83.

Abstract

We report a case of primary central nervous system (CNS) malignant lymphoma of the central nervous system originating from the cerebellum and growing along the lower cranial nerves. A 67-year-old woman presented with hoarseness, vertigo, nausea, and vomiting. Gd-DTPA enhanced MRI showed a homogeneous enhanced mass lesion extending from the cerebellum to the medulla oblongata around the jugular foramen on the right side. Although pre- and intra-operative diagnosis had been schwannoma, histopathological examination revealed a B-cell, diffuse malignant lymphoma. The growth pattern of malignant lymphoma in the present case, which extended extra-axially, is considered to be rare. We discuss here the growth patterns and difficulties of diagnosis of primary CNS malignant lymphoma in this area.

摘要

我们报告一例起源于小脑并沿下颅神经生长的原发性中枢神经系统(CNS)恶性淋巴瘤。一名67岁女性出现声音嘶哑、眩晕、恶心和呕吐。钆喷酸葡胺增强磁共振成像(Gd-DTPA enhanced MRI)显示一个均匀强化的肿块病变,从右侧小脑延伸至颈静脉孔周围的延髓。尽管术前和术中诊断为神经鞘瘤,但组织病理学检查显示为B细胞弥漫性恶性淋巴瘤。本例恶性淋巴瘤的生长模式为轴外生长,被认为较为罕见。我们在此讨论该区域原发性中枢神经系统恶性淋巴瘤的生长模式及诊断难点。

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