Secretion of an acid phosphatase (SapM) by Mycobacterium tuberculosis that is similar to eukaryotic acid phosphatases.
作者信息
Saleh M T, Belisle J T
机构信息
Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523-1677, USA.
出版信息
J Bacteriol. 2000 Dec;182(23):6850-3. doi: 10.1128/JB.182.23.6850-6853.2000.
Abstract
Mycobacterium tuberculosis secretes a large number of polypeptides with broad biological and immunological functions. We describe here the characterization of a 28-kDa acid phosphatase of M. tuberculosis (SapM) localized to the culture filtrate. The mature protein demonstrated biochemical characteristics similar to those of the bacterial nonspecific acid phosphatases. However, SapM yielded significant sequence homology to fungal acid phosphatases and not those of bacteria. Thus, SapM may represent a new class of bacterial nonspecific acid phosphatases.
摘要
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