Cabañas F, Pellicer A, Valverde E
Unidad de Neuroultrasonografía y Hemodinámica Cerebral Neonatal, Hospital Infantil La Paz, Madrid, España.
Rev Neurol. 2000;31(8):775-83.
The regulation of cerebral blood flow (CBF) is a determinant factor amongst the mechanisms involved in the development of neonatal brain lesions. Therefore it has been the main objective of many investigators in recent decades, seeking reliable techniques for measurement of cerebral haemodynamic parameters. However, the use of different techniques to assess brain haemodynamics has been limited by various factors including: harmlessness of the technique, its ease of use and accuracy of measurement. In this paper we aim to show how, using these techniques, together with sufficient understanding of neonatal pathophysiology, we can obtain better understanding of antenatal and perinatal factors responsible for cerebral damage, and the effect of this lesion on development. Besides using these findings to prevent specific disorders, we will obtain the advantage of an appropriate medical and neurosurgical treatment, with lower risk of neurological sequelae.
脑血流量（CBF）的调节是新生儿脑损伤发生机制中的一个决定性因素。因此，近几十年来，它一直是许多研究人员的主要目标，他们在寻找可靠的技术来测量脑血流动力学参数。然而，使用不同技术评估脑血流动力学受到多种因素的限制，包括：技术的无害性、易用性和测量准确性。在本文中，我们旨在展示如何通过使用这些技术，并充分理解新生儿病理生理学，更好地了解导致脑损伤的产前和围产期因素，以及这种损伤对发育的影响。除了利用这些发现预防特定疾病外，我们还将获得适当的药物和神经外科治疗的优势，降低神经后遗症的风险。
