Smith S M, Klein M R, Malin A S, Sillah J, Huygen K, Andersen P, McAdam K P, Dockrell H M
Immunology Unit, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Infect Immun. 2000 Dec;68(12):7144-8. doi: 10.1128/IAI.68.12.7144-7148.2000.
Intracellular flow cytometry analysis of perforin production by CD8(+) T cells showed levels were greatly reduced in tuberculosis (TB) patients compared to healthy controls. Reduced cytotoxic-T-lymphocyte activity was also obtained with CD8(+) T cells from TB patients compared to healthy controls in The Gambia. A change in antigen recognition was noted between the two groups of donors: in addition to recognition of Ag85A and Ag85B, as seen in healthy donors, a prominent ESAT-6 response was found in TB patients.
对CD8(+) T细胞产生穿孔素的细胞内流式细胞术分析显示,与健康对照相比,结核病(TB)患者的水平大幅降低。在冈比亚,与健康对照相比,TB患者的CD8(+) T细胞的细胞毒性T淋巴细胞活性也降低。两组供体之间发现了抗原识别的变化:除了如健康供体中所见的对Ag85A和Ag85B的识别外,在TB患者中还发现了显著的ESAT-6反应。