Taïeb S, Leblanc E, Bonodeau F, Vennin P, Fournier C, Besson P
Départements de Radiologie, Centre Oscar-Lambret, Lille, France.
J Gynecol Obstet Biol Reprod (Paris). 2000 Oct;29(6):555-63.
Some patients undergo laparoscopy without optimal debulking surgery as initial treatment for advanced ovarian carcinoma. The amount of residual tumor following primary surgery is an important prognosis factor. Neoadjuvant chemotherapy is a new therapeutic approach. Secondary, optimal surgery could be done in better conditions.
To access the ability of preoperative abdominopelvic CT to predict success of debulking surgery for ovarian carcinoma: less than 1cm of residual tumor size after initial surgery.
We reviewed 39 patients (two stage Ic, 1 stage IIc, 22 stage III and 14 stage IV) operated on for ovarian carcinoma between January 1992 and December 1997. Surgical criteria of inability to perform optimal surgical cytoreduction were compared with abdominopelvic CT done the month before. CT scans were prospectively assessed by radiologist A and retrospectively (3 months to 6 years delay) reviewed separately by radiologists A and B without surgical data.
Nineteen patients underwent optimal debulking surgery: 13 no residual tumor and 6 with residual lesions under 1cm. The interreader (0.73) and intrareader (0.9) agreement, worked out by Kappa coefficient, was judged good to very good. The sensitivity of CT was 91% with a specificity of 95%.
These results allowed us to determine which CT criteria were accurate and reproducible to be a helpful for therapeutic choice and to avoid laparotomy without optimal surgery.
一些晚期卵巢癌患者接受腹腔镜检查而非最佳肿瘤细胞减灭术作为初始治疗。初次手术后残留肿瘤的数量是一个重要的预后因素。新辅助化疗是一种新的治疗方法。其次,可以在更好的条件下进行二次最佳手术。
评估术前腹盆腔CT预测卵巢癌肿瘤细胞减灭术成功的能力:初次手术后残留肿瘤大小小于1cm。
我们回顾了1992年1月至1997年12月期间接受卵巢癌手术的39例患者(2例Ic期、1例IIc期、22例III期和14例IV期)。将无法进行最佳手术细胞减灭的手术标准与术前一个月进行的腹盆腔CT进行比较。CT扫描由放射科医生A进行前瞻性评估,并由放射科医生A和B在无手术数据的情况下分别进行回顾性评估(延迟3个月至6年)。
19例患者接受了最佳肿瘤细胞减灭术:13例无残留肿瘤,6例残留病灶小于1cm。通过Kappa系数计算得出的阅片者间(0.73)和阅片者内(0.9)一致性被判定为良好至非常好。CT的敏感性为91%,特异性为95%。
这些结果使我们能够确定哪些CT标准准确且可重复,有助于治疗选择并避免非最佳手术的剖腹手术。