Movin T
Department of Surgery, Anaesthesiology, Radiology and Orthopaedic Surgery, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
Scand J Med Sci Sports. 2000 Dec;10(6):368-71. doi: 10.1034/j.1600-0838.2000.010006368.x.
Mechanical load is regarded as the most important etiologic factor in cumulative trauma disorders affecting human tendons. At present there is limited knowledge concerning adaptation and the influence of training on human tendon tissue and the time process of developing a chronic tendon disorder. Tendon tissue samples and data concerning tendon pathology and repair have been derived from biopsies removed during surgery for rupture or pain conditions and from autopsy material. The ultrasound-guided percutaneous core biopsy technique provides the possibility to obtain tendon tissue from human Achilles and patellar tendon with limited discomfort for the individual. The specimens can be used for diagnostic purposes or for research and have the potential to highlight novel knowledge in, for example, the early stages of painful human tendon disorders. The fact that the procedure is invasive is a limitation. Autopsy material has limitations regarding poor information on case history, post mortem alterations and legal regulations on the use of tissue for medical purposes. The inflammatory process quickly affects ruptured tendons. The subcutaneous tendons that sustain a rupture are commonly characterized by degenerative alterations. Many tendon ruptures are treated with surgery, facilitating easy access to biopsy material. In summary, tendon tissue sampling in humans has obvious limitations. The recently described use of the core biopsy technique in human tendon research and diagnosis gives potential for new knowledge concerning human tendon adaptation, repair and disease.
机械负荷被认为是影响人类肌腱的累积性创伤疾病中最重要的病因。目前，关于人类肌腱组织的适应性、训练对其的影响以及慢性肌腱疾病发展的时间进程，我们所知有限。肌腱组织样本以及有关肌腱病理学和修复的数据，来自于因肌腱断裂或疼痛状况而在手术中取出的活检组织，以及尸检材料。超声引导下的经皮核心活检技术，为从人类跟腱和髌腱获取肌腱组织提供了可能，且对个体造成的不适有限。这些标本可用于诊断目的或研究，并有潜力揭示例如人类疼痛性肌腱疾病早期阶段的新知识。该操作具有侵入性这一事实是一个限制因素。尸检材料存在局限性，比如关于病史的信息不足、死后变化以及用于医疗目的的组织使用的法律法规问题。炎症过程会迅速影响断裂的肌腱。发生断裂的皮下肌腱通常具有退行性改变的特征。许多肌腱断裂通过手术治疗，这便于获取活检材料。总之，人类肌腱组织采样存在明显局限性。最近描述的核心活检技术在人类肌腱研究和诊断中的应用，为获取有关人类肌腱适应性、修复和疾病的新知识提供了潜力。
