Wade C E, Ortiz R M, Baer L A
Life Sciences Division, NASA Ames Research Center, Moffett Field, CA 94035-1000, USA.
Aviat Space Environ Med. 2000 Nov;71(11):1126-30.
To test the hypothesis that the body mass of rats is increased during spaceflight, we developed two models from the literature and obtained mass measurements during spaceflight. From studies of centrifugation (hypergravity), there is a reduction in body mass of rats dependent on the exposure gravity level. From data in 18 publications on rats subjected to hypergravity by centrifugation, we developed a model that predicted a 27% increase in body mass during the microgravity of spaceflight. Following spaceflight, with an increase in gravity on return to Earth, there is a reduction in body mass of rats for over 3 d. We related the reduction in body mass after spaceflight to the time after landing that mass measurements were made. From data in 23 publications on rats returning from spaceflight, we developed a model that predicted a 19% increase in body mass during spaceflight. Measurement of body mass of rats on days 6 and 10 of spaceflight found a 7 and 9% increase compared with ground control animals. The increase in body mass during spaceflight suggests that the rat may provide a viable model for metabolic studies in which changes during spaceflight may be predicted in part by ground-based hypergravity studies.
为了验证大鼠在太空飞行期间体重会增加这一假设，我们从文献中开发了两种模型，并在太空飞行期间获取了体重测量数据。从离心（超重力）研究中可知，大鼠的体重会随着暴露的重力水平而降低。根据18篇关于通过离心使大鼠处于超重力环境的出版物中的数据，我们开发了一个模型，该模型预测在太空飞行的微重力环境下大鼠体重会增加27%。太空飞行后，随着返回地球时重力增加，大鼠体重会在超过3天的时间里下降。我们将太空飞行后体重的下降与着陆后进行体重测量的时间联系起来。根据23篇关于从太空飞行返回的大鼠的出版物中的数据，我们开发了一个模型，该模型预测在太空飞行期间大鼠体重会增加19%。在太空飞行的第6天和第10天对大鼠体重进行测量发现，与地面对照动物相比，体重分别增加了7%和9%。太空飞行期间体重的增加表明，大鼠可能为代谢研究提供一个可行的模型，其中太空飞行期间的变化部分可以通过地面超重力研究来预测。
