作为前胶原C蛋白酶抑制剂的二肽和三肽异羟肟酸的固相合成
Solid-phase synthesis of di- and tripeptidic hydroxamic acids as inhibitors of procollagen C-proteinase.
作者信息
Dankwardt S M, Billedeau R J, Lawley L K, Abbot S C, Martin R L, Chan C S, Van Wart H E, Walker K A
机构信息
Roche Bioscience, Inflammatory Diseases Unit, Palo Alto, CA 94304, USA.
出版信息
Bioorg Med Chem Lett. 2000 Nov 20;10(22):2513-6. doi: 10.1016/s0960-894x(00)00525-4.
Abstract
A solid-phase approach to the rapid synthesis of di- and tripeptide-like hydroxamic acids is presented. These compounds are shown to be potent inhibitors of procollagen C-proteinase (PCP).
摘要
本文介绍了一种快速合成二肽和三肽样异羟肟酸的固相方法。这些化合物被证明是前胶原C蛋白酶（PCP）的有效抑制剂。
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