在胚胎中建立左右轴。

Establishing a left-right axis in the embryo.

作者信息

Ryan A K, Izpisúa Belmonte J C

机构信息

Department of Medicine, University of California San Diego, La Jolla 92093-0648, USA.

出版信息

IUBMB Life. 2000 Jul;50(1):1-11. doi: 10.1080/15216540050176520.

DOI:10.1080/15216540050176520

PMID:11087114

Abstract

Vertebrates exhibit evolutionarily conserved asymmetries in the pattern of internal organ placement that are essential for their normal physiological function. Left-right asymmetries in organ situs are dependent upon the formation of an intact left-right axis during embryogenesis. Recently many of the molecular components involved in the initiation and maintenance of the left-right axis have been described. These molecules and their function in promoting left-right asymmetries are reviewed.

摘要

脊椎动物在内部器官布局模式上表现出进化上保守的不对称性，这对其正常生理功能至关重要。器官位置的左右不对称取决于胚胎发育过程中完整的左右轴的形成。最近，许多参与左右轴起始和维持的分子成分已被描述。本文对这些分子及其在促进左右不对称方面的功能进行了综述。