Ipsapirone suppresses food intake in food-deprived rats by an action at 5-HT(1A) receptors.

The effects of the 5-HT(1A) receptor agonist ipsapirone (2.5-10 mg/kg, s.c.) on food intake were investigated in rats that had been fasted for 22 h. Ipsapirone administered immediately prior to presentation of food produced a dose-related decrease in food intake. The effect of ipsapirone (5 mg/kg) was reversed by pretreatment with the 5-HT(1A) receptor antagonist N-[2[4-)2-methoxyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexaneca rboxamide trihydrochloride (WAY100635) (0.3 mg/kg, s.c.). The results of this study show that ipsapirone has acute dose-dependent depressant effects on food intake in fasted rats, mediated by 5-HT(1A) receptors.