Fugger L, Svejgaard A
Department of Clinical Immunology, Aarhus University Hospital, Skejby Sygehus, Denmark.
Arthritis Res. 2000;2(3):208-11. doi: 10.1186/ar89. Epub 2000 Apr 25.
Inherited susceptibility to rheumatoid arthritis (RA) is associated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 molecules. Transgenic mice expressing these major histocompatibility complex (MHC) class II molecules have been developed to generate humanized models for RA. The relevance of these models for understanding RA will be discussed.
类风湿关节炎(RA)的遗传易感性与编码人类白细胞抗原(HLA)-DR4和HLA-DR1分子的DRB1基因相关。已经培育出表达这些主要组织相容性复合体(MHC)II类分子的转基因小鼠,以生成RA的人源化模型。将讨论这些模型对于理解RA的相关性。