[基因组甲基化及其在真核生物功能中的作用]

[Genome methylation and its role in functioning of the eukaryotic organism].

作者信息

Prokhorchuk A V, Ruzov A S

机构信息

Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.

出版信息

Genetika. 2000 Nov;36(11):1475-86.

PMID:11094764

Abstract

Methylation is a modification that changes the structure and functional status of DNA. Hence it is interesting to study the effect of methylation on basic processes occurring in living cells. In this review, the role of DNA methylation in recombination, replication, transcription regulation, imprinting, tumorigenesis, and tumor progression is considered.

摘要

甲基化是一种改变DNA结构和功能状态的修饰。因此，研究甲基化对活细胞中发生的基本过程的影响很有意思。在这篇综述中，我们考虑了DNA甲基化在重组、复制、转录调控、印记、肿瘤发生和肿瘤进展中的作用。