Fitzgerald D W, Morse M M, Pape J W, Johnson W D
Groupe Haitien d'Etude du Sarcome de Kaposi et des Infections Opportunistes, Port au Prince, Haiti.
Clin Infect Dis. 2000 Dec;31(6):1495-7. doi: 10.1086/317485.
A review was conducted in Haiti to determine the timing and outcome of active tuberculosis (TB) in human immunodeficiency virus (HIV)-positive patients who had previously received isoniazid (INH) prophylaxis. Of 1005 HIV-seropositive patients who completed INH prophylaxis, 14 (1.4%) subsequently had active TB diagnosed. The median interval between discontinuation of INH prophylaxis and TB diagnosis was 8 months for 6 patients receiving 6 months of INH, 22 months for 5 patients receiving 12-24 months of INH, and 40 months for 3 patients receiving 24-36 months of INH (P = .026). There is a postprophylaxis effect on INH that is dependent upon the duration of therapy.
在海地进行了一项回顾性研究，以确定曾接受异烟肼（INH）预防性治疗的人类免疫缺陷病毒（HIV）阳性患者发生活动性结核病（TB）的时间和结果。在1005例完成INH预防性治疗的HIV血清阳性患者中，有14例（1.4%）随后被诊断为活动性TB。接受6个月INH治疗的6例患者，停止INH预防性治疗至TB诊断的中位间隔时间为8个月；接受12 - 24个月INH治疗的5例患者为22个月；接受24 - 36个月INH治疗的3例患者为40个月（P = 0.026）。INH预防性治疗后存在一种效应，该效应取决于治疗持续时间。
