Gatchalian R A, Popli A, Ejaz A A, Leehey D J, Kjellstrand C M, Ing T S
Department of Medicine, Veterans Affairs Hospital, Hines, IL 60141, USA.
Am J Kidney Dis. 2000 Dec;36(6):1262-6. doi: 10.1053/ajkd.2000.19843.
Intensive high-flux hemodiafiltration is often used in the management of vancomycin toxicity. We describe two patients who developed hypophosphatemia as a consequence of this form of therapy. The first patient was treated with an intravenous phosphorus infusion. For the second patient, hypophosphatemia was corrected, during hemodiafiltration, with the use of a phosphorus-enriched dialysate. The latter dialysate was prepared by adding sodium phosphate salts to the "base concentrate" of a dual-concentrate, bicarbonate-based dialysate delivery system. This simple method was more efficient than intravenous therapy in ameliorating the hypophosphatemia secondary to aggressive hemodiafiltration treatment.
强化高通量血液透析滤过常用于治疗万古霉素毒性。我们描述了两名因这种治疗方式而发生低磷血症的患者。第一名患者接受了静脉输注磷治疗。对于第二名患者，在血液透析滤过期间，使用富含磷的透析液纠正了低磷血症。后一种透析液是通过向双浓缩、碳酸氢盐基透析液输送系统的“基础浓缩液”中添加磷酸钠盐制备的。在改善积极的血液透析滤过治疗继发的低磷血症方面，这种简单方法比静脉治疗更有效。
