Erickson J D, Varoqui H
Neuroscience Center, Louisiania State University Health Sciences Center, New Orleans, Louisiana 70112, USA.
FASEB J. 2000 Dec;14(15):2450-8. doi: 10.1096/fj.00-0206rev.
Vesicular transporters are responsible for the loading of neurotransmitters into specialized secretory organelles in neurons and neuroendocrine cells to make them available for regulated neurosecretion. The exocytotic release of neurotransmitter therefore depends on the functional activity of the vesicular transporters and their efficient sorting to these secretory organelles. Molecular analysis of vesicular transport proteins has revealed important information regarding structural domains responsible for their functional properties, including substrate specificity and trafficking to various classes of secretory vesicles. These studies have established the existence of an important functional relationship between transporter activity and presynaptic quantal neurosecretion.
囊泡转运体负责将神经递质装载到神经元和神经内分泌细胞中的特殊分泌细胞器中，以便它们可用于调节性神经分泌。因此，神经递质的胞吐释放取决于囊泡转运体的功能活性及其向这些分泌细胞器的有效分选。对囊泡转运蛋白的分子分析揭示了有关负责其功能特性的结构域的重要信息，包括底物特异性和向各类分泌囊泡的运输。这些研究确立了转运体活性与突触前量子神经分泌之间重要的功能关系的存在。
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