Oettgen H C
Division of Immunology, Children's Hospital, Harvard Medical School, 300 Longwood Avenue, 02115, Boston, MA 02115, USA.
Curr Opin Immunol. 2000 Dec;12(6):618-23. doi: 10.1016/s0952-7915(00)00153-9.
In allergic responses, B cells are driven to undergo an immunoglobulin isotype switch, shifting from IgM to IgE synthesis. This process involves the rearrangement of germline DNA in the immunoglobulin heavy-chain locus and is stimulated by cytokines (IL-4 and IL-13) and CD40 activation. It is now evident that cytokine-induced 'germline' epsilon-RNA transcripts associate with DNA in the genomic switch region (S epsilon) to form DNA-RNA hybrid structures, which target nucleases in for deletional switch recombination. Alterations in cytokine production and signaling affect the efficiency of this process and are associated with inherited predisposition to allergy.
在过敏反应中，B细胞被驱动进行免疫球蛋白同种型转换，从合成IgM转变为合成IgE。这个过程涉及免疫球蛋白重链基因座中种系DNA的重排，并受到细胞因子（IL-4和IL-13）和CD40激活的刺激。现在很明显，细胞因子诱导的“种系”ε-RNA转录本与基因组转换区域（Sε）中的DNA结合，形成DNA-RNA杂交结构，这些结构靶向核酸酶以进行缺失性转换重组。细胞因子产生和信号传导的改变会影响这一过程的效率，并与遗传性过敏易感性相关。
