Anderlik P, Szeri I, Bános S, Radnai B
Acta Microbiol Acad Sci Hung. 1975;22(1):27-31.
The course and histological picture of intracerebral LCM virus infection was found to differ in mice with their thymus displaying an age-dependent involution and in young adult animals. Signs of lymphocytic choriomeningitis were absent in 75 per cent of the aged animals. The change of the characteristic clinical and histological picture referred to the decreased cellular immune response of aged animals, ascribed to the age-dependent involution of the thymus.
研究发现,脑内淋巴细胞性脉络丛脑膜炎病毒(LCM病毒)感染的病程和组织学表现,在胸腺呈现年龄依赖性退化的小鼠和年轻成年动物中有所不同。75%的老龄动物没有淋巴细胞性脉络丛脑膜炎的症状。特征性临床和组织学表现的变化归因于老龄动物细胞免疫反应的降低,这与胸腺的年龄依赖性退化有关。